Men’s Health and Medical Cannabis: What the Science Actually Says About Prostate Cancer, Sleep, and Hormones

Men’s health is complex and deeply interconnected, and many men struggle with issues that often go untreated. Prostate cancer, poor sleep quality, low energy and hormonal changes are common concerns that affect quality of life, performance, and long-term health.

While cannabis is not a cure for disease, research continues to reveal compelling ways that cannabinoids may support men’s health when used with proper medical guidance. At DeMonet, our goal is to help men understand the evidence, make informed choices, and access expert medical support through online consultations with Dr. Ife Abiola.

Below, we break down three key areas where medical cannabis may play a role in men’s health.

Prostate Cancer and Cannabidiol: What the Research Shows

Prostate cancer is the second most common cancer in men worldwide. Over the past decade, researchers have begun exploring how cannabinoids, particularly cannabidiol (CBD), interact with prostate cancer cells in the lab.

While these studies are preclinical, the findings are promising.

CBD shows anticancer activity in prostate cancer cells

A 2023 study published in PLOS ONE found that CBD had notable effects on PC3 prostate cancer cells in vitro.Key findings include:

• A reduction in cancer cell viability by up to 37.25 percent

• Activation of apoptosis, also known as programmed cell death

• Visible DNA fragmentation in cancer cells

• Upregulation of Bax, a gene that encourages cancer cells to self-destruct

These results were observed in laboratory cell cultures, not humans, but they reveal important potential mechanisms.

CBD may enhance the effects of chemotherapy

Another 2023 study published in Cannabis and Cannabinoid Research examined CBD in combination with etoposide, a chemotherapy drug often used in prostate cancer.

The combination showed:

• Greater reduction in cancer cell survival

• Higher levels of apoptosis

• Stronger activation of caspase pathways

• Increased oxidative stress within cancer cells

• Upregulation of pro-apoptotic genes and downregulation of anti-apoptotic genes

Why this matters

Together, these findings suggest that CBD may act as an adjunct therapy by:

• Reducing cancer cell survival

• Encouraging cancer cell death

• Increasing sensitivity to traditional chemotherapy

• Shifting gene expression toward anticancer activity

These studies do not mean CBD treats prostate cancer, but they highlight how cannabinoids may one day support conventional cancer therapies. Men who are exploring symptom management, treatment support, or quality of life improvements should consult a qualified medical professional.

If you or a loved one is navigating prostate cancer treatment and want to understand whether cannabinoids may be appropriate, book a private consultation with Dr. Ife Abiola.

Sleep, Recovery, and the Role of Cannabinoids in Men’s Health

Poor sleep is one of the most overlooked factors affecting men’s physical and mental health.Statistics show that 43 per cent of men struggle with falling or staying asleep.

Quality sleep impacts:

• Muscle protein synthesis

• Recovery after workouts

• Hormonal balance

• Cognitive function

• Energy levels and mood

  
  

One week of sleeping less than five hours has been shown to reduce testosterone levels by about 15 per cent. This has real consequences for strength, metabolism, libido, and overall vitality.

How cannabinoids affect the sleep-wake cycle

The endocannabinoid system plays a regulatory role in sleep. Activation of CB1 receptors influences the serotonergic system, which helps regulate circadian rhythm.

THC and sleep

Research shows that THC can:

• Increase stage 3 slow wave sleep

• Shorten sleep onset time

• Reduce nightmares

• Improve subjective sleep quality in the short term

  
  

A large-scale survey found that:

• 56.2% of participants experienced deeper sleep with THC

• 41.6% slept longer

• 36.3% had fewer night time awakenings

  
  

Chronic use may reduce these benefits, which is why proper dosing and medical oversight is important.

CBN for nighttime awakening and sleep continuity

CBN, a weaker CB1 agonist, offers sedative properties without the sympathetic nervous system stimulation associated with THC.

A 2024 double-blind study found that 50 mg of CBN led to:

• Reduced night time awakenings

• Fewer sleep disturbances

• No daytime fatigue

• No added benefit when combined with CBD

This makes CBN a promising option for men who want sleep support without feeling impaired or groggy.

The key insight

Sleep is not one size fits all. THC may help with sleep onset, CBN may help with sleep continuity, and CBD may offer calming effects for anxiety-driven insomnia. The right cannabinoid and dose depend on each person’s biology and health history.

A medical consultation with Dr. Ife Abiola can help men identify which cannabinoid profile is best suited to their sleep challenges.

Hormones, Testosterone, and the Endocannabinoid System

Men often ask whether cannabis affects testosterone or other hormones. The answer is more nuanced than people assume.

The endocannabinoid system interacts with the hypothalamic pituitary gonadal (HPG) axis, which regulates testosterone and reproductive hormones.

What the research shows

Data from the U.S. National Health and Nutrition Examination Survey found:

• Serum testosterone levels were inversely associated with time since last cannabis useThis means the more recent the cannabis use, the higher the testosterone level measured.

• A broader dataset of 5,146 men, adjusted for age, BMI, alcohol, tobacco, comorbidities, exercise, and race found:

• A small but statistically significant increase in testosterone among regular THC users

• The strongest increase was seen in men who used THC two to three times per month

• These men showed an average increase of 66.77 ng per dL in testosterone levels compared to non-users

This demonstrates an inverse U-shaped trend, where light to moderate use was associated with the greatest hormonal change.

What this means for men

Cannabis affects hormones through multiple pathways, but the effects differ by:

• Dose

• Frequency

• Cannabinoid profile

• Individual metabolic differences

For some men, the right cannabinoid regimen may support sleep, recovery, libido, and overall hormonal balance. For others, misuse or overuse may have the opposite effect.

A personalized medical assessment is essential for uncovering what is appropriate and safe.

Are you curious how medical cannabis could support your health?

Medical cannabis is not a one-size-fits-all solution and should never be approached with guesswork. The science is evolving, and each man’s body, hormones, and health needs are different.

This is why we offer private online medical assessments with a medical doctor and cannabis expert, who provides:

• Evidence-based guidance

• Personalized cannabinoid plans

• Support for sleep, recovery, hormones, and symptom management

• Monitoring and adjustments over time

If you want to explore whether medical cannabis is right for you, or if you are managing prostate cancer, chronic sleep issues, or hormonal concerns, booking a consultation is the safest and most effective first step.

Book your private online assessment today.

Take control of your health with expert guidance tailored to your needs.